CAS 9004-34-6, pH 5 - 7.5. In Cellulose and Cellulose Derivatives in the Food Industry, T. Wstenberg (Ed. [FMC Study Number I92-1464]. HMo@9, U Q!R/1*;` However, with many different grades (standard and specialty) on offer, how do you select the correct material for your needs? INCI.
!(!0*21/*.-4;K@48G9-.BYBGNPTUT3? To help, weve put together a simple guide for selecting Avicel Microcrystalline cellulose grades, with simple explanations of some of the most common grades, plus recommendations that will serve the majority of buyers. PDF (28.38 mb) 2022 Corporate Fact Sheet. CAS #: 9004-34-6 The short-term limit for total inhalable dust is 20 mg/m3. Since cellulose contains both amorphous and crystalline regions, when the crystalline regions are mechanically and chemically isolated and elaborated, various useful ingredients in the form of cellulose crystals are obtained, one of which is Avicel Microcrystalline cellulose. Some substance identifiers may have been claimed confidential, or may . BIOACCUMULATIVE POTENTIAL The current product range and recommended usage are summarised below: Microcrystalline Cellulose is currently listed in the United States Pharmacopoeia and National Formulary, the European Pharmacopeia, the Japanese Pharmacopoeia, the British Pharmacopoeia, in addition to the Indian and Chinese Pharmacopeia, to name but a few. However, it yields non-digestible fibre. undefined. The global microcrystalline cellulose (MCC) market was valued at $401.1 million in 2021, and is projected to reach $712.9 million by 2031, growing at a CAGR of 5.9% from 2022 to 2031. Cellulose microcrystalline MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents. q9;v80q>jZ %PDF-1.5
It is widely used within the pharmaceutical, food, and cosmetic sectors as a formulation aid. It is generally regarded as a relatively nontoxic and non-irritant material that is safe for human and animal consumption. We respect your privacy FMC Privacy Policy. 51395-75-6 Avicel RC 591. 86dXeaAjHe%d*`&>>&_p}=X|_% fTtC
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The representative usage of Avicel PH-101 and Avicel PH-102 Microcrystalline cellulose in wet granulation and direct compression is shown in the following two examples. In the late 1960s, Avicel Microcrystalline cellulose was registered in the supplement to the National Formulary as a pharmaceutical excipient. Product Name: Microcrystalline Cellulose E460 1.2. Note that Avicel Microcrystalline cellulose is available in different particle sizes and moisture grades that have different properties and applications. Although the breakup of cellulose to form colloidal microcrystalline cellulose has no impact on calorific content of the material, colloidal microcrystalline cellulose contain soluble components (hydrocolloids) that are introduced during processing, which add calories to the product. Watch Now. The United States Food and Drug Administration considers microcrystalline cellulose a safe material for all animal species. It can be processed both via wet granulation and direct compression, as well as roller compression and extrusion-spheronisation. For this reason, nutritionists regard standard powdered microcrystalline cellulose as having zero energy content. It is an excipient approved for use in pharmaceutical products and is also GRAS listed and accepted for use as a food additive in Europe and the United States and is included in the FDA Inactive Ingredients Database (oral: powders, suspensions, syrups, and tablets; topical & vaginal products). Explore our end markets, products, ingredients and essential solutions or get in touch with us about your order. FMC Corporation. Interestingly, the discovery of Avicel was accidental, the team was attempting to break up hydrolysed cellulose . MATERIAL SAFETY DATA SHEET Avicel PH Microcrystalline Cellulose MSDS Ref. Eur., JPE . <<
However, if handling bulk powders, observance of appropriate safeguards is recommended. pfTr^i5wOg)y .6
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3Fz. It is highly versatile and is therefore also widely used in topicals and semi-solid & liquid dosage forms, including ointments, creams, gels, pastes, solutions, suspensions, and emulsions. };khd5x=fr Thus, Avicel contributes no or very few calories to the food system. Molecular Weight null. JRS Pharma: PROSOLV SMCC 90: Microcrystalline Cellulose, Colloidal Silicon Dioxide: 125: 0.25 - 0.37: Formulas in which a balance of flow and compaction is required. Cellulose microcrystalline. Hi, let us know if you have any questions as you visit our website. ChemicalBook. These include amphiphilicity, a higher degree of crystallinity, surface area, higher hydration properties, and morphology. Learn about our new global sustainability platform, Learn about FMC's industry leading goal of net-zero emissions by 2035, Learn about FMC's differentiated biologically-based crop solutions. Microcrystalline cellulose (Avicel, FMC Corporation) is prepared by acid hydrolysis of cellulose using 2 M hydrochloric acid at 105 C for 15 min. Avicel CL-611 Microcrystalline Cellulose and Sodium Carboxymethylcellulose Manufacturer FMC Corporation Product code 103-B Revision date 2014 September 30 Language English. IDENTIFICATION OF THE SUBSTANCE/PREPARATION AND THE COMPANY/UNDERTAKING Material Name: Estradiol Tablets Trade Name: RONFASE . Their nomenclature and recommended applications are shown below: Co-processed Avicel grades are high functionality materials designed to bring added performance over and above what standard grades offer. GRINDSTED Xanthan Gum readily dissolves in water under ambient conditions without the need of special high-shear equipment. 1.5% w/w), especially designed for formulating active pharmaceutical ingredients (APIs) with a high sensitivity for moisture. on Avicel microcrystalline cellulose, the most trusted excipient brand for decades. This Microcrystalline Cellulose . Product Specifications: Chemical and Physical: Loss on drying, % NMT 6.0* Viscosity, cps, 1.2% solids, 120 sec 39 to 91 . Various Gelcarin and Viscarin carrageenan grades are used by the pharmaceutical industry to achieve specific gelling for controlled drug release, thickening, and stabilizing properties desired in various formulations. Avicel is one of the best-known pharmaceutical excipient brands and, without doubt, one of the most frequently used raw materials in solid oral product formulation and manufacture. To overcome the pitfalls of known overlays, we tested suspensions of microcrystalline cellulose Avicel RC/CLtrade mark as overlay media in the plaque and plaque-inhibition assay of influenza viruses. Browse Avicel PH-101 and related products at MilliporeSigma. $4%&'()*56789:CDEFGHIJSTUVWXYZcdefghijstuvwxyz ? Earth Supplied Products LLC. YUMPU automatically turns print PDFs into web optimized ePapers that Google loves. } !1AQa"q2#BR$3br AFFINISOL HPMC HME offers hot melt extrusion process flexibility in choosing a polymer viscosity that optimizes drug release profiles and against the factors affecting solubility. AFFINISOL HPMC has been specifically designed for generating solid dispersions via spray-drying (SDD) or hot melt extrusion (HME) in the pharmaceutical industry. Chemical Formula: (C6H10O5)n 1.4. The figure below illustrates the structural organisation of cellulose within plants. Microcrystalline Cellulose NF. Copyright 2023 by International Flavors & Fragrances Inc. IFF is a Registered Trademark. <<
An internally cross-linked sodium carboxymethyl cellulose (NaCMC), it aids in the disintegration and drug dissolution of pharmaceutical tablets, capsules, and granules. . In extrusion-spheronisation, it is the excipient of choice. Quantity: 1 700 kgs. Material safety data sheet (MSDS) of the m icrocrystalline cellu lose (MCC) SDS - Safety Data Sheet. Ac-Di-Sol Croscarmellose Sodium is one of our flagship offerings for pharmaceutical manufacturers. Upon ingestion, microcrystalline cellulose is not absorbed into the blood stream and therefore has little toxicological potential. Delivering efficient and robust formulations. (&E. All Rights Reserved. CoA. AFFINISOL hydroxypropyl methylcellulose (HPMC) is a water-soluble cellulosic polymer that can help optimize solubility enhancement of poorly soluble drugs by maintaining stable solid dispersions and inhibiting API crystallization. ECOLOGICAL INFORMATION ECOTOXICITY Practically nontoxic to fish: Rainbow trout LC50 (96hr) > 100%, saturated solution (Microcrystalline cellulose, Avicel PH-101) PERSISTENCE AND BIODEGRADABILITY Inherently biodegradable. Avicel RC-591 & CL-611 - Description. !,K`I[O@U|$+i 8sB|+"B@'2^7[2XKrd#5b ]2}Sb2Wdn-;^}n(/;r\'l3--l~
kuI?H>$7;!l|g|i4&dtb/O3!C!#\qpg+>Q0OM HAZARDS IDENTIFICATION EMERGENCY TELEPHONE NUMBERS (302) 451-0100 (FMC Plant - Newark, Delaware) (303) 595-9048 (Medical - U.S. - Call Collect) For leak, fire, spill, or accident emergencies, call: (800) 424-9300 (CHEMTREC - U.S.A. & Canada) (703) 527-3887 (CHEMTREC - Collect - All Other Countries) EMERGENCY OVERVIEW: Off-white, free-flowing, odorless powder. The wood pulp is depolymerized by acid hydrolysis and turned from a fibrous material to a white freely-flowing powder. Molecular weight: Not Applicable 1.5. The aqueous solution to barrier membrane coating. FIRST AID MEASURES Eye Contact Hold eyes open and rinse slowly and gently with water for 15 to 20 minutes. %PDF-1.4
AVICEL RC 581. Cellulose, microcrystalline | C14H26O11 | CID 14055602 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological . If you have Crohn's disease or a history of bowel obstruction, discuss with a doctor or pharmacist about drug interactions with fiber supplements.. Microcrystalline cellulose has excellent compressibility properties and is widely used in solid forms such as tablets that are hard, but can dissolve quickly, and this has increased its demand in . Microcrystalline cellulose is produced by subjecting to a high shear treatment, at elevated temperature and pressure, a reaction mixture of a cellulose material, an active oxygen compound and water, for a time effective to depolymerize the cellulose material. The most. 1 0 obj
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X`I%&/m{JJt`$@iG#)*eVe]f@{{;N'?\fdlJ!?~|? Chemical Formula: (C6H10O5)n 1.4. The application areas for Avicel Microcrystalline cellulose are immense and encompass many industrial sectors such as food, pharmaceuticals, and cosmetics. Are you looking for information about products and services by region? (Microcrystalline Cellulose Market Pr. 3 0 obj
Within the pharmaceuticals field, where the bulk of this material is utilised, Avicel Microcrystalline cellulose functions as a filler and diluent, dry binder, flow, disintegrating, and compression aid in tablets, capsules, and granules. Slightly soluble in 5% w/v sodium hydroxide solution; practically insoluble in water, dilute acids, and most organic solvents. Avicel Microcrystalline Cellulose: A Guide to Grades and Uses, Working Hours (Mon to Friday): 08:30 - 17:30, legendary Canadian-born chemist, Orlando Aloysius Battista, United States Pharmacopoeia and National Formulary, United States Food and Drug Administration, Quantitative nutritional analysis of Avicel Microcrystalline cellulose (in 100g), https://doi.org/10.1016/0378-5173(95)04231-8, https://doi.org/10.1016/j.ejpb.2004.05.009, https://doi.org/10.1002/9783527682935.ch04, Pharmaceutical Acronyms and Abbreviations, Glossary of Terms Used in the Pharmaceutical Industry, Standard Terms & Conditions Of Sale Of Goods And Services, 4-O-[(1S)-hexopyranosyl]-D-glycero-hexopyranose. FMC BioPolymer 1735 Market Street Philadelphia, PA 19103 (800) 526-3649 . Solid dispersions are one of the key technologies for formulating oral solid dosage forms containing APIs with bioavailability challenges. Place an order online, track your orders, download SDS and TDS, and see your quotes, all in one secure place. JFIF ` ` ZExif MM * J Q Q Q C
There have always been two different points of view for the liquidity of MCC. This is unlikely to be a problem when Microcrystalline cellulose is consumed as part of a medical product where it is used as an excipient in the formulation. Stabilizer composition of co-attrited microcrystalline cellulose and carboxymethylcellulose, method for making, and uses CN103842425B . : 5 This document has been prepared to meet the requirements of the U.S. OSHA Hazard Communication Standard, 29 CFR 1910.1200 and Canadas Workplace Hazardous Materials Information System (WHMIS) requirements. Low use levels of GRINDSTED Xanthan Gum are sufficient to provide desired viscosities and textures. Learn about FMC's differentiated biologically-based crop solutions. High performance lubricant that brings more to the tablet. Microcrystalline Cellulose (MCC) MSDS 1. Microcrystalline Cellulose / Avicel PH-102. Avicel Microcrystalline cellulose is available in many grades, which differ in particle size, bulk density, and moisture content. FMC, JRS and Mingtai were estimated to hold for . Avicel Microcrystalline cellulose occurs as a white, odourless, tasteless, fibrous powder composed of porous particles. The product range encompasses methylcellulose and hydroxypropyl methylcellulose (hypromellose) each available in different grades to address a wide range of applications including tablet coatings, granulation, controlled release, drug layering, vegetarian hard-shell capsules and amorphous drug stabilization. Enter your [postal] code to see information about local products, representatives and retailers, along with special offers in your area. No. No. GENERIC EU MSDS - NO COUNTRY SPECIFIC DATA - NO OEL DATA 1. FMC has deep roots in the food production system worldwide learn more about our latest advances in the future of agriculture. Product and Company Identification Product Name Microcrystalline Cellulose CAS Number 9004-34-6 Parchem - fine & specialty chemicals 415 Huguenot Street New Rochelle, NY 10801 (914) 654-6800 (914) 654-6899 parchem.com info@parchem.com EMERGENCY RESPONSE NUMBER Cellulose microcrystalline Revision Date 25-Dec-2021 SARA 313 Not applicable SARA 311/312 Hazard CategoriesSee section 2 for more information CWA (Clean Water Act) Not applicable Clean Air Act Not applicable OSHA - Occupational Safety and Health Administration Not applicable CERCLA Not applicable California Proposition 65 This product contains the following Proposition 65 chemicals. ( *r_ *?~4$
&0Y# Biologicals by FMC. If you are already a ChemPoint customer then sign up for access to our online ordering website. Ac-Di-Sol Croscarmellose Sodium is one of our flagship offerings for pharmaceutical manufacturers. CAS 9004-34-6. l~5C
Examination of urine, blood and faecal levels of vitamin B 1 during microcrystalline cellulose ingestion showed no difference from control periods (Anonymous, 1966). (Microcrystalline Cellulose) DATE PREPARED: 1/7/2016 Page 1 of 4 Section 1. It flows and compresses extremely well, properties that endear this material wide scope of use in many fields. {iy7uEijn0y]"s"gbV~p8Q)zN:cyvs]&,kk=6pcA %iBW|2nKa)Jb7` 0
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